… may produce a modest inhibition of cytochrome P450 (CYP) 1A2’[4]. However, the findings
of the present study with caffeine and tizanidine indicate that rofecoxib is a potent inhibitor of …

… on tizanidine pharmacokinetics suggest that rofecoxib can … In the in vivo studies with healthy
volunteers, rofecoxib (25 mg … Rofecoxib has inhibited the metabolism of caffeine in healthy …

… Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine
in healthy subjects… The purpose of this study was to investigate the effect of rofecoxib, several …

… We recently discovered that rofecoxib is a potent mechanism-based inhibitor of … to humans,
does not inhibit the metabolism of tizanidine or the formation of paraxanthine from caffeine, …

… The interaction between tizanidine and CYP1A2 inhibitors has … Studies have also shown
that furafylline reduces caffeine … and explored the inhibitory effect of rofecoxib on CYP1A2. The …

… Tizanidine is more sensitive than caffeine and theophylline as a probe substrate for … time
profile for tizanidine (upper panel) and rofecoxib (lower panel) in healthy volunteers. Included in …

… (6-hydroxylation) and tizanidine (oxidation) are also used as … enzyme activity as measured
by the rate of caffeine 3-… patients (n = 75) and healthy volunteers (n = 159). Among asthmatic …

… data of 21 naturally occurring flavonoids against caffeine N … studies have demonstrated
that typical CYP1A2 inhibitors are … the major excretory route for tizanidine and its metabolites, …

… The nonsteroidal anti-inflammatory drug (NSAID) rofecoxib … of tizanidine after a single 4-mg
oral dose in 10 healthy subjects, … tizanidine concentration or the caffeine test in humans. …

… Rofecoxib also increased the urinary excretion of tizanidine … of tizanidine and its metabolite
M3 in healthy volunteers (n = … no significant effect on the caffeine-paraxanthine ratio. Since …